House vacation rentals in Eastern Antioquia

Find and book unique houses on Airbnb

Top-rated house rentals in Eastern Antioquia

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Guest favorite

Home in Peñol

4.9 out of 5 average rating, 118 reviews

Enjoy Nature, Relax & Reset at Casa Chevere!

Casa Chévere is the ideal getaway for friends and family to relax & reset! Wake up to stunning views of Lake Guatapé, surrounded by lush greenery and birds chirping while you enjoy fresh breakfast arepas! Highlights include: - 8-person hot tub - FAST Starlink WiFi - Full kitchen, BBQ, fire pit - 15 mins to La Piedra - 25-min to Guatape Please Note: Unfortunately due to the ongoing drought in Colombia, the lake has receded from the house, so the use of the kayaks is not possible at the moment.

Superhost

Home in Medellín

4.76 out of 5 average rating, 174 reviews

Comfortable house in Manila! A/C - WiFi 300 Mb

• Entire House in Best Location: Walk Score 99 out of 100 in Poblado Heart! Walk to groceries, supermarkets, dining, cafes, parks. All delivery apps reach the house • 3 Bedrooms, 2 bathrooms, dedicated workspace and living room • A/C in 2 bedrooms • Ethernet plug-in • Fully equipped kitchen • High speed, reliable 300Mbps WiFi • Strictly cleaned and sanitized • Contactless self check-in with your personal access code • Extremely safe neighborhood • Less than 10 min walk to Poblado and Lleras Park

Guest favorite

Home in Medellin

4.95 out of 5 average rating, 173 reviews

Charming House Provenza|Tropical Garden|Jacuzzi|AC

This 4 bedroom house in Provenza in El Poblado is right on ''restaurant row''. Best location, walk in less then 5 minutes to all the top restaurants, clubs, shops and Lleras Park. Spectacular private 1200 sq. ft. tropical garden with 4 person jacuzzi for relaxing, coffee and grilling. A/C in every bedroom. Fast 200MB Wi-Fi and workspaces. Ideal for groups of friends, families, long term travelers and digital nomads. *December 24' installed new jacuzzi, remodeled master bathroom &second bathroom

Superhost

Home in San Rafael

4.88 out of 5 average rating, 121 reviews

Private villa for 10-48, w/Starlink. Near Guatapé

Welcome to our sprawling 110-hectare ranch in Colombia’s Paisa heartland—a private oasis designed for groups of any size, from intimate gatherings of 10 to grand parties of up to 48 guests! Perfect for family reunions, celebrations, or retreats, this exclusive-use retreat blends rustic charm with modern comforts. Airbnb bookings accommodate 1-16 guests (default 10); for larger groups, simply message us. Extra guests beyond your booking are 70,000 COP/night (kids under 3 free, 3-7 half price).

Guest favorite

Home in Puerto Triunfo

4.88 out of 5 average rating, 128 reviews

Casa Creta - Doradal - Colombian Santorini

Beautiful Mediterranean house with terrace in Santorini Colombiano Doradal, 2.5km from Hacienda Naples, 20 minutes of reservation Natural Rio Claro, close to the bus terminal, restaurants, supermarket and pharmacies. The house is great for families and groups of friends. It has air conditioning and fans in all spaces, 2 bedrooms, 2 bathrooms, dining room and equipped kitchen, washing machine. 2 double beds, 1 single bed and a double sofa bed in the living room and tv (sleeps 7 people).

Top guest favorite

Home in Medellín

5 out of 5 average rating, 74 reviews

Casa Alba Medellin

Experience the epitome of luxury and seclusion at this exquisite retreat in Medellin. With breathtaking views, total privacy, and easy access to the airport, this oasis offers a true escape from daily life. Enjoy a heated pool, jacuzzi, outdoor fireplace, and kitchen. Each bedroom has AC. Immerse yourself in nature and indulge in the vibrant city's nightlife just a short drive away. Discover the perfect blend of tranquility and opulence at this remarkable sanctuary NO PARTIES ALLOWED

Top guest favorite

Home in El Peñol

4.98 out of 5 average rating, 59 reviews

New Luxury Cabin Jacuzzi Sauna Fireplace Best View

Spacious home featuring two Queen-size beds, one double bed, and two single beds, with an additional sofa bed that can be used as a double bed! Everything you could wish for in a property with the best view of the beautiful mountains and the iconic Peñol Rock, one of the most visited attractions in Antioquia. The amenities speak for themselves in a central & easily accessible location, reachable by car, and just a two-block walk to the nearby marina so you can rent my Jetski & boat!

Superhost

Home in Fredonia

4.87 out of 5 average rating, 61 reviews

Finca Naya: Adventure, Coffee, and Waterfalls

Escape to the serene hills of Colombia and immerse yourself in the breathtaking beauty of the Finca Naya Coffee Plantation. Surrounded by lush green coffee trees, this wholesome retreat offers a harmonious blend of nature and coffee. Experience the magic of the Colombian countryside with its tropical blooms, rolling hills, and cascading waterfalls, all set to the melody of birdsong. Book your stay now and discover the wonders of the Finca Naya Coffee Plantation.

Guest favorite

Home in Guatape

4.85 out of 5 average rating, 162 reviews

Guatape cabin house with a view of the lake and the Peñol

Municipio del Peñol -Guatapé Entire accommodation for 7 people with hot water, located 5 min from the pier and in front of the peñol stone where you can enjoy beautiful sunsets that make this place a quiet, family and unforgettable space, friendly to animals, maximum 2 pets with parking for three vehicles. Nightly prices. DIRECT NEGOTIATION ONLY FOR the AIRBNB PLATFORM, due to drought time there may be water outages eb kas nights, 11pm-5am approx

Guest favorite

Home in Antioquia

4.94 out of 5 average rating, 139 reviews

Architectural Award Winning Home - Lakeside, Views

Winner of the SARA NY Design Award of Honor, & recently featured in AXXIS Architectural Magazine, this hilltop hand poured concrete home is located in the most exclusive area of Guatape, 10 min from town 360’ views, lake access & only 3 other properties on the 4 acre site, the setting is quiet & private Enjoy sunset views from the rooftop balcony or plunge bath. Note: Access is a 100 meter path with a moderate climb

Guest favorite

Home in Medellín

5 out of 5 average rating, 7 reviews

Modern Astorga House

Perfect for both small and large groups, this versatile home offers two separate units that can be rented individually or combined into one spacious retreat. Each unit features cozy bedrooms, fully-equipped kitchens, and comfortable living areas. Ideal for families, friends, or group getaways, it’s located in a vibrant area close to local attractions. Enjoy flexibility, privacy, and convenience all in one place.

Guest favorite

Home in Medellín

4.91 out of 5 average rating, 57 reviews

2. Comfortable studio apartment in Laureles, Medellín

Welcome to our cozy internal studio in the beautiful Laureles area in Medellin! This apartment is perfect for those looking for a comfortable and convenient stay in one of the most vibrant areas of the city. Located near shopping centers (Unicentro, Los Molinos), health centers (Clínica Vida la 80, clinic las américas), tourist sites (Comuna 13, Pueblito Paisa, la 70), convenience stores and restaurants.